Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Middle Region) Peptide
SIGLEC10
适用: 人
宿主: 合成
BP, WB
Quick Overview for Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Middle Region) Peptide (ABIN983734)
抗原
SIGLEC10
(Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- Middle Region
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产品特性
- This is a synthetic peptide designed for use in combination with anti-SIGLEC10 antibody (Catalog #: ARP50160_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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纯化方法
- Purified
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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浓度
- 1 mg/mL
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缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
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背景
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SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SIGLEC10 preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC10 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-653 AC008750.9 90495-91147 c 654-760 DA387605.1 391-497 761-2959 AF301007.1 262-2460 2960-3794 AY358337.1 1930-2764
Alias Symbols: MGC126774, PRO940, SIGLEC-10, SLG2
Protein Interaction Partner: FLNA,PTPN6
Protein Size: 697 -
分子量
- 76 kDa
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基因ID
- 89790
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NCBI登录号
- NM_033130, NP_149121
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UniProt
- Q96LC7
抗原
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